|Other Accession||NM_175058, NP_778228|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Rat, Rabbit, Chicken, Horse, Bovine, Guinea Pig, Dog|
|Other Names||Pleckstrin homology domain-containing family A member 7, PH domain-containing family A member 7, PLEKHA7|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-PLEKHA7 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PLEKHA7 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site.|
|Cellular Location||Cell junction, adherens junction. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to zonula adherens, recruited via its interaction with CTNND1|
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Provided below are standard protocols that you may find useful for product applications.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
Brill L.M.,et al.Anal. Chem. 76:2763-2772(2004).
Meng W.,et al.Cell 135:948-959(2008).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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