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Ubxn2a antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | D3ZID8 |
| Other Accession | NM_001109482, NP_001102952 |
| Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Chicken, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 29kDa |
| Gene ID | 685859 |
|---|---|
| Alias Symbol | Ubxd4 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Ubxn2a antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Ubxn2a antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Ubxn2a {ECO:0000312|RGD:1589027} |
|---|---|
| Function | Acts to repress the ubiquitination and subsequent endoplasmic reticulum-associated degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons (PubMed:26265139). Also acts to promote the translocation of CHRNA3 to the plasma membrane and subsequently increases plasma membrane acetylcholine-gated ion-channel activation (By similarity). Plays a role in the inhibition of STUB1-mediated TP53 degradation, via its interaction with HSPA9 which acts to inhibit TP53 binding to HSPA9 (By similarity). Positively mediates the ubiquitination and proteosomal degradation of RICTOR, may thereby act as a negative regulator of the mTORC2 pathway (By similarity). |
| Cellular Location | Golgi apparatus. Endoplasmic reticulum. Perikaryon {ECO:0000250|UniProtKB:Q99KJ0}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99KJ0}. Nucleus {ECO:0000250|UniProtKB:P68543} Cytoplasm. Note=Expressed at the axon initial segment. {ECO:0000250|UniProtKB:Q99KJ0} |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 389.00
Cat# AI13549
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