APH1B Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | Q8WW43 |
Other Accession | NM_031301, NP_112591 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 28kDa |
Gene ID | 83464 |
---|---|
Alias Symbol | APH-1B, PRO1328, PSFL, TAAV688 |
Other Names | Gamma-secretase subunit APH-1B, APH-1b, Aph-1beta, Presenilin-stabilization factor-like, APH1B, PSFL |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-APH1B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
Precautions | APH1B Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | APH1B |
---|---|
Synonyms | PSFL |
Function | Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. |
Cellular Location | Membrane; Multi-pass membrane protein |
Tissue Location | Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Lee H.-J.,et al.Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
Saito S.,et al.Biochem. Biophys. Res. Commun. 330:1068-1072(2005).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.