|Other Accession||NM_031301, NP_112591|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Bovine, Guinea Pig, Dog|
|Alias Symbol||APH-1B, PRO1328, PSFL, TAAV688|
|Other Names||Gamma-secretase subunit APH-1B, APH-1b, Aph-1beta, Presenilin-stabilization factor-like, APH1B, PSFL|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 &mu, l of distilled water. Final Anti-APH1B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||APH1B Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain.|
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Provided below are standard protocols that you may find useful for product applications.
Lee H.-J.,et al.Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
Saito S.,et al.Biochem. Biophys. Res. Commun. 330:1068-1072(2005).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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