|Other Accession||NM_031272, NP_112562|
|Reactivity||Human, Rat, Rabbit, Horse|
|Predicted||Human, Rabbit, Horse|
|Other Names||Inactive serine/threonine-protein kinase TEX14, Protein kinase-like protein SgK307, Sugen kinase 307, Testis-expressed sequence 14, Testis-expressed sequence 14 protein, TEX14, SGK307|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-TEX14 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TEX14 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity).|
|Cellular Location||Cytoplasm. Midbody. Chromosome, centromere, kinetochore Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell division.|
|Tissue Location||Detected in testis.|
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Provided below are standard protocols that you may find useful for product applications.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Wang P.J.,et al.Nat. Genet. 27:422-426(2001).
Wu M.-H.,et al.Gene Expr. Patterns 3:231-236(2003).
Iwamori T.,et al.Mol. Cell. Biol. 30:2280-2292(2010).
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