|Other Accession||NM_013919, NP_038947|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||ESTM28, Usp16, Usp23, W53272|
|Other Names||Ubiquitin carboxyl-terminal hydrolase 21, 22.214.171.124, Deubiquitinating enzyme 21, Ubiquitin thioesterase 21, Ubiquitin-specific-processing protease 21, Usp21, Usp23|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Usp21 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Usp21 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin- 1 conjugates. Deubiquitinates BAZ2A/TIP5 leading to its stabilization (By similarity).|
|Cellular Location||Cytoplasm. Nucleus|
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Smith T.S.,et al.Biochim. Biophys. Acta 1490:184-188(2000).
Carninci P.,et al.Science 309:1559-1563(2005).
Nakagawa T.,et al.Genes Dev. 22:37-49(2008).
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