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Usp21 Antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - Usp21 Antibody - N-terminal region AI13648

    Host: Rabbit
    Target Name: Usp21
    Sample Tissue: Mouse Brain lysates
    Antibody Dilution: 1.0μg/ml
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9QZL6
Other Accession NM_013919, NP_038947
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 62kDa
Additional Information
Gene ID 30941
Alias Symbol ESTM28, Usp16, Usp23, W53272
Other Names Ubiquitin carboxyl-terminal hydrolase 21, 3.4.19.12, Deubiquitinating enzyme 21, Ubiquitin thioesterase 21, Ubiquitin-specific-processing protease 21, Usp21, Usp23
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Usp21 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsUsp21 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Usp21 {ECO:0000303|PubMed:18172164, ECO:0000312|MGI:MGI:1353665}
Function Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:18172164). Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation (PubMed:18172164). Regulates gene expression via histone H2A deubiquitination (PubMed:18172164). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (By similarity). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q9UK80}. Nucleus {ECO:0000250|UniProtKB:Q9UK80}
Research Areas
Citations (0)
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References

Smith T.S.,et al.Biochim. Biophys. Acta 1490:184-188(2000).
Carninci P.,et al.Science 309:1559-1563(2005).
Nakagawa T.,et al.Genes Dev. 22:37-49(2008).

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$ 389.00
Cat# AI13648
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