|Other Accession||NM_001033053, NP_001028225|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Horse, Bovine, Dog|
|Alias Symbol||CARD7, CLR17.1, DEFCAP, DEFCAP-L/S, DKFZp586O1822, KIAA0926, NAC, NALP1, PP1044, SLEV1, VAMAS1|
|Other Names||NACHT, LRR and PYD domains-containing protein 1, Caspase recruitment domain-containing protein 7, Death effector filament-forming ced-4-like apoptosis protein, Nucleotide-binding domain and caspase recruitment domain, NLRP1, CARD7, DEFCAP, KIAA0926, NAC, NALP1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-NLRP1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||NLRP1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CARD7, DEFCAP, KIAA0926, NAC, NALP1|
|Function||Able to form cytoplasmic structures termed death effector filaments. Enhances APAF1 and cytochrome c-dependent activation of pro-caspase-9 and consecutive apoptosis. Stimulates apoptosis through activation of caspase-3. Involved in activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of IL1B and IL18. Binds ATP.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed. Isoform 1 and isoform 2 are expressed in peripheral blood leukocytes and chronic myelogenous leukemia cell line K-562, followed by thymus, spleen and heart Also detected in brain, lung, placenta, small intestine, colon, kidney, liver, muscle, testis and epithelial cells. Absent from hematopoietic progenitor cells but expressed upon differentiation of cells into granulocytes and, to a lesser extent, monocytes. In peripheral blood cells, highest levels are found in T-lymphocytes, granulocytes and monocytes. Expression is significantly increased in bone marrow blast cells of some acute leukemia patients but not in solid tumors. Expressed in adult cornea as well as adult and 24-week fetal tissues, including choroid, sclera, cornea, optic nerve, and adult retina and fetal retina/retinal pigment epithelium. In addition, expressed in corneal epithelia obtained during photorefractive keratectomy.|
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Provided below are standard protocols that you may find useful for product applications.
Bertin J.,et al.Cell Death Differ. 7:1273-1274(2000).
Martinon F.,et al.Curr. Biol. 11:R118-R120(2001).
Hlaing T.,et al.J. Biol. Chem. 276:9230-9238(2001).
Chu Z.-L.,et al.J. Biol. Chem. 276:9239-9245(2001).
Nagase T.,et al.DNA Res. 6:63-70(1999).
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