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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   NLRP1 antibody - N-terminal region   

NLRP1 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - NLRP1 antibody - N-terminal region AI13653

    WB Suggested Anti-NLRP1 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:62500
    Positive Control: NCI-H226 cell lysate
    .NLRP1 is strongly supported by BioGPS gene expression data to be expressed in NCI-H226
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9C000
Other Accession NM_001033053, NP_001028225
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 155kDa
Additional Information
Gene ID 22861
Alias Symbol CARD7, CLR17.1, DEFCAP, DEFCAP-L/S, DKFZp586O1822, KIAA0926, NAC, NALP1, PP1044, SLEV1, VAMAS1
Other Names NACHT, LRR and PYD domains-containing protein 1, Caspase recruitment domain-containing protein 7, Death effector filament-forming ced-4-like apoptosis protein, Nucleotide-binding domain and caspase recruitment domain, NLRP1, CARD7, DEFCAP, KIAA0926, NAC, NALP1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-NLRP1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsNLRP1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRP1
Synonyms CARD7, DEFCAP, KIAA0926, NAC, NALP1
Function Able to form cytoplasmic structures termed death effector filaments. Enhances APAF1 and cytochrome c-dependent activation of pro-caspase-9 and consecutive apoptosis. Stimulates apoptosis through activation of caspase-3. Involved in activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of IL1B and IL18. Binds ATP.
Cellular Location Cytoplasm. Nucleus
Tissue Location Widely expressed. Isoform 1 and isoform 2 are expressed in peripheral blood leukocytes and chronic myelogenous leukemia cell line K-562, followed by thymus, spleen and heart Also detected in brain, lung, placenta, small intestine, colon, kidney, liver, muscle, testis and epithelial cells. Absent from hematopoietic progenitor cells but expressed upon differentiation of cells into granulocytes and, to a lesser extent, monocytes. In peripheral blood cells, highest levels are found in T-lymphocytes, granulocytes and monocytes. Expression is significantly increased in bone marrow blast cells of some acute leukemia patients but not in solid tumors. Expressed in adult cornea as well as adult and 24-week fetal tissues, including choroid, sclera, cornea, optic nerve, and adult retina and fetal retina/retinal pigment epithelium. In addition, expressed in corneal epithelia obtained during photorefractive keratectomy.
Research Areas
Citations (0)

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Bertin J.,et al.Cell Death Differ. 7:1273-1274(2000).
Martinon F.,et al.Curr. Biol. 11:R118-R120(2001).
Hlaing T.,et al.J. Biol. Chem. 276:9230-9238(2001).
Chu Z.-L.,et al.J. Biol. Chem. 276:9239-9245(2001).
Nagase T.,et al.DNA Res. 6:63-70(1999).

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$ 293.00
Cat# AI13653
(40 western blots)
Availability: 2-3 days
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