FLII antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC |
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Primary Accession | Q13045 |
Other Accession | NM_002018, NP_002009 |
Reactivity | Human, Mouse, Rat, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Chicken, Horse, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 145kDa |
Gene ID | 2314 |
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Alias Symbol | FLI, FLIL, Fli1, MGC39265 |
Other Names | Protein flightless-1 homolog, FLII, FLIL |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-FLII antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | FLII antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FLII |
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Synonyms | FLIL |
Function | May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. |
Cellular Location | Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, focal adhesion Note=Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes (By similarity). |
Tissue Location | Strongest expression in skeletal muscle with high expression also in the heart and lung. |
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Provided below are standard protocols that you may find useful for product applications.
References
Campbell H.D.,et al.Genomics 42:46-54(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).
Campbell H.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:11386-11390(1993).
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