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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Loxl2 antibody - C-terminal region   

Loxl2 antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - Loxl2 antibody - C-terminal region AI13669

    WB Suggested Anti-Loxl2 Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Heart
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P58022
Other Accession NM_033325, NP_201582
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Chicken, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 85kDa
Additional Information
Gene ID 94352
Alias Symbol 1110004B06Rik, 4930526G11Rik, 9430067E15Rik, MGC102220
Other Names Lysyl oxidase homolog 2,, Lysyl oxidase-like protein 2, Loxl2
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Loxl2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsLoxl2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Loxl2
Function Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E- cadherin, probably by mediating deamination of histone H3 (By similarity). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
Cellular Location Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus Chromosome. Note=Associated with chromatin (By similarity). It is unclear how LOXL2 is nuclear: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed the intracellular location and its key role in transcription regulation.
Tissue Location Ubiquitous. Highest expression in skin, lung and thymus. Present in chondrocytes: mainly expressed by chondrocytes in healing fractures and in epiphyseal growth plates (at protein level).
Research Areas
Citations (0)

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Carninci P.,et al.Science 309:1559-1563(2005).
Jourdan-Le Saux C.,et al.Matrix Biol. 19:179-183(2000).
Bignon M.,et al.Blood 118:3979-3989(2011).
Iftikhar M.,et al.J. Biol. Chem. 286:909-918(2011).

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$ 293.00
Cat# AI13669
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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