|Other Accession||NM_033325, NP_201582|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Chicken, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||1110004B06Rik, 4930526G11Rik, 9430067E15Rik, MGC102220|
|Other Names||Lysyl oxidase homolog 2, 22.214.171.124, Lysyl oxidase-like protein 2, Loxl2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Loxl2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Loxl2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E- cadherin, probably by mediating deamination of histone H3 (By similarity). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.|
|Cellular Location||Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus Chromosome. Note=Associated with chromatin (By similarity). It is unclear how LOXL2 is nuclear: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed the intracellular location and its key role in transcription regulation.|
|Tissue Location||Ubiquitous. Highest expression in skin, lung and thymus. Present in chondrocytes: mainly expressed by chondrocytes in healing fractures and in epiphyseal growth plates (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Carninci P.,et al.Science 309:1559-1563(2005).
Jourdan-Le Saux C.,et al.Matrix Biol. 19:179-183(2000).
Bignon M.,et al.Blood 118:3979-3989(2011).
Iftikhar M.,et al.J. Biol. Chem. 286:909-918(2011).
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