|Other Accession||NM_013522, NP_038550|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Chicken, Goat, Bovine, Guinea Pig, Dog|
|Other Names||Protein FRG1, FSHD region gene 1 protein, Frg1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Frg1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Frg1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N- methyltransferase SUV420H1.|
|Cellular Location||Nucleus, Cajal body. Nucleus, nucleolus. Cytoplasm. Cytoplasm, myofibril, sarcomere, Z line. Note=Localization changes during myogenesis from mainly cytoplasmic in undifferentiated myoblasts, to strongly nucleolar in early myotubes and back to cytoplasmic 5 days post- differentiation. Localized at the Z-line in the sarcomere of matured myotubes 8 days post-differentiation|
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Provided below are standard protocols that you may find useful for product applications.
Grewal P.K.,et al.Gene 216:13-19(1998).
Carninci P.,et al.Science 309:1559-1563(2005).
Gabellini D.,et al.Nature 439:973-977(2006).
Hanel M.L.,et al.Differentiation 81:107-118(2011).
Neguembor M.V.,et al.J. Mol. Cell Biol. 5:294-307(2013).
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