|Other Accession||NM_005323, NP_005314|
|Reactivity||Human, Rabbit, Pig, Dog|
|Alias Symbol||H1FT, H1t, MGC163222, dJ221C16.2|
|Other Names||Histone H1t, Testicular H1 histone, HIST1H1T, H1FT, H1T|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-HIST1H1T antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||HIST1H1T antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable).|
|Cellular Location||Nucleus. Chromosome|
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Provided below are standard protocols that you may find useful for product applications.
Drabent B.,et al.Gene 103:263-268(1991).
Koppel D.A.,et al.J. Cell. Biochem. 54:219-230(1994).
Marzluff W.F.,et al.Genomics 80:487-498(2002).
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