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IFIT5 antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - IFIT5 antibody - middle region AI13709

    Host: Rabbit
    Target Name: CHAD
    Sample Tissue: Human Adult Placenta
    Antibody Dilution: 1.0μg/ml
    detail
  • WB - IFIT5 antibody - middle region AI13709

    Host:Rabbit
    Target Name:IFIT5
    Sample Tissue:Human Fetal Muscle
    Antibody Dilution: 1.0μg/ml
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q13325
Other Accession NM_012420, NP_036552
Reactivity Human, Mouse, Rat, Pig, Horse, Bovine, Dog
Predicted Human, Pig, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 56kDa
Additional Information
Gene ID 24138
Alias Symbol RI58
Other Names Interferon-induced protein with tetratricopeptide repeats 5, IFIT-5, Interferon-induced 58 kDa protein, Retinoic acid- and interferon-inducible 58 kDa protein, P58, IFIT5, ISG58, RI58
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-IFIT5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsIFIT5 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IFIT5
Synonyms ISG58, RI58
Function Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268). Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non- self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420). Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268). Additionally, as a mediator in innate immunity, positively regulates IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 (PubMed:26334375).
Cellular Location Cell projection, ruffle membrane. Note=Colocalized with RIGI at cell surface ruffles. Localizes to actin-rich protrusions from the apical cell surface
Research Areas
Citations (0)
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References

Niikura T.,et al.Blood Cells Mol. Dis. 23:337-349(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 389.00
Cat# AI13709
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