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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   VPS4A antibody - N-terminal region   

VPS4A antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - VPS4A antibody - N-terminal region AI13710

    WB Suggested Anti-VPS4A Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:312500
    Positive Control: Human Muscle
  • WB - VPS4A antibody - N-terminal region AI13710

    Host: Rabbit
    Target Name: VPS4A
    Sample Tissue: Human Fetal Heart
    Antibody Dilution: 1.0μg/ml
  • WB - VPS4A antibody - N-terminal region AI13710

    Host: Rabbit
    Target Name: VPS4A
    Sample Tissue: Human Fetal Lung
    Antibody Dilution: 1.0μg/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UN37
Other Accession NM_013245, NP_037377
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 49kDa
Additional Information
Gene ID 27183
Alias Symbol FLJ22197, SKD1, SKD2, VPS4, VPS4-1, SKD1A
Other Names Vacuolar protein sorting-associated protein 4A,, Protein SKD2, VPS4-1, hVPS4, VPS4A {ECO:0000312|EMBL:AAG01470.1}
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-VPS4A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsVPS4A antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VPS4A {ECO:0000312|EMBL:AAG01470.1}
Function Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515).
Cellular Location Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Midbody. Note=Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells, interaction with ZFYVE19/ANCHR mediates retention at midbody (PubMed:24814515). Localized in two distinct rings on either side of the Fleming body
Tissue Location Ubiquitously expressed.
Research Areas
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$ 293.00
Cat# AI13710
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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