Mfsd7b antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | B2RXV4 |
Other Accession | NM_001081259, NP_001074728 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 60kDa |
Gene ID | 226844 |
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Alias Symbol | 9630055N22Rik, FLVCR, Flvcr1 |
Other Names | Feline leukemia virus subgroup C receptor-related protein 1, Feline leukemia virus subgroup C receptor, Major facilitator superfamily domain containing 7B, Mfsd7b, Flvcr1, Mfsd7b |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Mfsd7b antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Mfsd7b antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Flvcr1 |
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Synonyms | Mfsd7b |
Function | [Isoform 1]: Heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythropoiesis, a process in which heme synthesis intensifies. Possibly export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. The molecular mechanism of heme transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated. |
Cellular Location | [Isoform 1]: Cell membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
References
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Keel S.B.,et al.Science 319:825-828(2008).
Chiabrando D.,et al.J. Clin. Invest. 122:4569-4579(2012).
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