|Other Accession||NM_001081259, NP_001074728|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||9630055N22Rik, FLVCR, Flvcr1|
|Other Names||Feline leukemia virus subgroup C receptor-related protein 1, Feline leukemia virus subgroup C receptor, Major facilitator superfamily domain containing 7B, Mfsd7b, Flvcr1, Mfsd7b|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Mfsd7b antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Mfsd7b antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro (By similarity). Required during erythtopoiesis to maintain intracellular free heme balance since in proerythroblasts, heme synthesis intensifies and it's accumulation is toxic for cells.|
|Cellular Location||Isoform 1: Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Keel S.B.,et al.Science 319:825-828(2008).
Chiabrando D.,et al.J. Clin. Invest. 122:4569-4579(2012).
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