|Application ||WB, IHC|
|Other Accession||NM_015122, NP_055937|
|Reactivity||Human, Mouse, Rat, Pig, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Pig, Bovine, Guinea Pig, Dog|
|Other Names||FCH domain only protein 1, FCHO1, KIAA0290|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-FCHO1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||FCHO1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.|
|Cellular Location||Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes|
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Provided below are standard protocols that you may find useful for product applications.
Ohara O.,et al.DNA Res. 4:53-59(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Sakaushi S.,et al.Biosci. Biotechnol. Biochem. 71:1764-1768(2007).
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