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FCHO1 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | O14526 |
| Other Accession | NM_015122, NP_055937 |
| Reactivity | Human, Mouse, Rat, Pig, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Pig, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 97kDa |
| Gene ID | 23149 |
|---|---|
| Alias Symbol | KIAA0290 |
| Other Names | FCH domain only protein 1, FCHO1, KIAA0290 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-FCHO1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | FCHO1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FCHO1 (HGNC:29002) |
|---|---|
| Synonyms | KIAA0290 |
| Function | Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). |
| Cellular Location | Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side Note=Associated with forming but not mature clathrin-coated vesicles The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes |
| Tissue Location | Predominantly expressed in lymphoid cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Ohara O.,et al.DNA Res. 4:53-59(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Sakaushi S.,et al.Biosci. Biotechnol. Biochem. 71:1764-1768(2007).
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