PHACTR1 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC |
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Primary Accession | Q9C0D0 |
Other Accession | NM_030948, NP_112210 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Chicken, Horse, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 66kDa |
Gene ID | 221692 |
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Alias Symbol | KIAA1733, MGC126575, MGC126577, RPEL, RPEL1, dJ257A7.2 |
Other Names | Phosphatase and actin regulator 1, PHACTR1, KIAA1733, RPEL1 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-PHACTR1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | PHACTR1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PHACTR1 |
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Synonyms | KIAA1733, RPEL1 |
Function | Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). |
Cellular Location | Cytoplasm. Synapse. Nucleus. Note=Enriched at synapses (By similarity) Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import (By similarity). |
Tissue Location | Detected in umbilical vein endothelial cells. |
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Provided below are standard protocols that you may find useful for product applications.
References
Nagase T.,et al.DNA Res. 7:347-355(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Jarray R.,et al.Biochimie 93:1668-1675(2011).
Allain B.,et al.Cell. Signal. 24:214-223(2012).
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