|Application ||WB, IHC|
|Other Accession||NM_030948, NP_112210|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Chicken, Horse, Bovine|
|Alias Symbol||KIAA1733, MGC126575, MGC126577, RPEL, RPEL1, dJ257A7.2|
|Other Names||Phosphatase and actin regulator 1, PHACTR1, KIAA1733, RPEL1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-PHACTR1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PHACTR1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. Plays a role in cell motility. Plays a role in the formation of tubules by endothelial cells. Regulates PPP1CA activity. Required for normal cell survival.|
|Cellular Location||Cytoplasm. Cell junction, synapse. Nucleus. Note=Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import (By similarity).|
|Tissue Location||Detected in umbilical vein endothelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
Nagase T.,et al.DNA Res. 7:347-355(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Jarray R.,et al.Biochimie 93:1668-1675(2011).
Allain B.,et al.Cell. Signal. 24:214-223(2012).
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