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Bin1 antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - Bin1 antibody - middle region AI13796

    WB Suggested Anti-Bin1 Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Pancreas
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O08539
Other Accession NM_009668, NP_033798
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Chicken, Horse, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 65kDa
Additional Information
Gene ID 30948
Alias Symbol ALP-1, Amphl, BRAMP-2, SH3P9
Other Names Myc box-dependent-interacting protein 1, Amphiphysin II, Amphiphysin-like protein, Bridging integrator 1, SH3 domain-containing protein 9, Bin1, Amphl, Sh3p9
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Bin1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsBin1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Bin1
Synonyms Amphl, Sh3p9
Function Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:12183633). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:12668730, PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:O00499}. Cytoplasm. Endosome Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O08839}
Tissue Location Isoform 1 is expressed mainly in the brain. Isoform 2 is widely expressed.
Research Areas
Citations (0)
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References

Leprince C.,et al.J. Biol. Chem. 272:15101-15105(1997).
Sparks A.B.,et al.Nat. Biotechnol. 14:741-744(1996).
Modregger J.,et al.J. Biol. Chem. 278:4160-4167(2003).
Ballif B.A.,et al.Mol. Cell. Proteomics 3:1093-1101(2004).
Trinidad J.C.,et al.Mol. Cell. Proteomics 5:914-922(2006).

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$ 389.00
Cat# AI13796
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