Bin1 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | O08539 |
Other Accession | NM_009668, NP_033798 |
Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Chicken, Horse, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 65kDa |
Gene ID | 30948 |
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Alias Symbol | ALP-1, Amphl, BRAMP-2, SH3P9 |
Other Names | Myc box-dependent-interacting protein 1, Amphiphysin II, Amphiphysin-like protein, Bridging integrator 1, SH3 domain-containing protein 9, Bin1, Amphl, Sh3p9 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Bin1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Bin1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Bin1 |
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Synonyms | Amphl, Sh3p9 |
Function | Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:12183633). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:12668730, PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (By similarity). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:O00499}. Cytoplasm. Endosome Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O08839} |
Tissue Location | Isoform 1 is expressed mainly in the brain. Isoform 2 is widely expressed. |
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Provided below are standard protocols that you may find useful for product applications.
References
Leprince C.,et al.J. Biol. Chem. 272:15101-15105(1997).
Sparks A.B.,et al.Nat. Biotechnol. 14:741-744(1996).
Modregger J.,et al.J. Biol. Chem. 278:4160-4167(2003).
Ballif B.A.,et al.Mol. Cell. Proteomics 3:1093-1101(2004).
Trinidad J.C.,et al.Mol. Cell. Proteomics 5:914-922(2006).
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