|Other Accession||NM_144792, NP_659041|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||9530058O11Rik, AI841905, C80702, MGC30540, Mob, Sms1, Sor1, Tmem23|
|Other Names||Phosphatidylcholine:ceramide cholinephosphotransferase 1, 220.127.116.11, Protein Mob, Sphingomyelin synthase 1, Transmembrane protein 23, Sgms1, Tmem23|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Sgms1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Sgms1 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types (By similarity). Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.|
|Cellular Location||Golgi apparatus membrane; Multi-pass membrane protein|
|Tissue Location||Isoform 1 is widely expressed, isoform 2 shows a more narrow distribution and isoform 3 is detected only in testis and heart.|
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Provided below are standard protocols that you may find useful for product applications.
Yang Z.,et al.Gene 363:123-132(2005).
Carninci P.,et al.Science 309:1559-1563(2005).
Huitema K.,et al.EMBO J. 23:33-44(2004).
Yang Z.,et al.FEMS Yeast Res. 6:751-762(2006).
Li Z.,et al.Arterioscler. Thromb. Vasc. Biol. 32:1577-1584(2012).
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