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Sgms1 Antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8VCQ6 |
| Other Accession | NM_144792, NP_659041 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 46kDa |
| Gene ID | 208449 |
|---|---|
| Alias Symbol | 9530058O11Rik, AI841905, C80702, MGC30540, Mob, Sms1, Sor1, Tmem23 |
| Other Names | Phosphatidylcholine:ceramide cholinephosphotransferase 1, 2.7.8.27, Protein Mob, Sphingomyelin synthase 1, Transmembrane protein 23, Sgms1, Tmem23 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Sgms1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Sgms1 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Sgms1 |
|---|---|
| Synonyms | Tmem23 |
| Function | Major sphingomyelin synthase at the Golgi apparatus (By similarity). Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes (By similarity). Does not use free phosphorylcholine or CDP- choline as donor. Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (PubMed:22580896, PubMed:16879426) (By similarity). Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (By similarity). |
| Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:Q86VZ5}; Multi-pass membrane protein |
| Tissue Location | Isoform 1 is widely expressed, isoform 2 shows a more narrow distribution and isoform 3 is detected only in testis and heart. |
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Yang Z.,et al.Gene 363:123-132(2005).
Carninci P.,et al.Science 309:1559-1563(2005).
Huitema K.,et al.EMBO J. 23:33-44(2004).
Yang Z.,et al.FEMS Yeast Res. 6:751-762(2006).
Li Z.,et al.Arterioscler. Thromb. Vasc. Biol. 32:1577-1584(2012).
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$ 389.00
Cat# AI13800
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