|Other Accession||NM_028113, NP_082389|
|Reactivity||Human, Mouse, Rat, Rabbit|
|Alias Symbol||2600011E07Rik, Amer2, Fam123a|
|Other Names||APC membrane recruitment protein 2, Amer2, Protein FAM123A, Amer2, Fam123a|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Fam123a antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Fam123a antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity).|
|Cellular Location||Cell membrane; Peripheral membrane protein. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2.|
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