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A730011L01Rik antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - A730011L01Rik antibody - middle region AI13834

    WB Suggested Anti-A730011L01Rik Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Brain
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q8C9A2
Other Accession NM_001164636, NP_001158108
Reactivity Human, Mouse, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 37kDa
Additional Information
Gene ID 338371
Alias Symbol Endov, A730011L01Rik
Other Names Endonuclease V, 3.1.26.-, Endov
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-A730011L01Rik antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsA730011L01Rik antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Endov
Function Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Active against both single-stranded and double-stranded RNAs. Has strong preference for single-stranded RNAs (ssRNAs) toward double- stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q8N8Q3}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8N8Q3}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q8N8Q3}. Note=Relocalizes to cytoplasmic stress granules upon cellular stress where it colocalizes with PABPC1 {ECO:0000250|UniProtKB:Q8N8Q3}
Tissue Location Highest levels detected in liver with high levels also found in heart, kidney and testis. Expressed at low levels in brain.
Citations (0)
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References

Moe A.,et al.Nucleic Acids Res. 31:3893-3900(2003).
Carninci P.,et al.Science 309:1559-1563(2005).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 389.00
Cat# AI13834
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