|Other Accession||NM_001164636, NP_001158108|
|Reactivity||Human, Mouse, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||Endov, A730011L01Rik|
|Other Names||Endonuclease V, 3.1.26.-, Endov|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-A730011L01Rik antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||A730011L01Rik antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Endoribonuclease that specifically cleaves inosine- containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'- UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures (By similarity).|
|Cellular Location||Cytoplasm. Nucleus, nucleolus.|
|Tissue Location||Highest levels detected in liver with high levels also found in heart, kidney and testis. Expressed at low levels in brain.|
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Provided below are standard protocols that you may find useful for product applications.
Moe A.,et al.Nucleic Acids Res. 31:3893-3900(2003).
Carninci P.,et al.Science 309:1559-1563(2005).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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