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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Bloc1s2 antibody - N-terminal region   

Bloc1s2 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - Bloc1s2 antibody - N-terminal region AI13840

    WB Suggested Anti-Bloc1s2 Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Heart
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9CWG9
Other Accession NM_028607, NP_082883
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog
Predicted Human, Chicken, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 15kDa
Additional Information
Gene ID 73689
Alias Symbol 2410089B13Rik, BLOS2
Other Names Biogenesis of lysosome-related organelles complex 1 subunit 2, BLOC-1 subunit 2, Bloc1s2, Blos2
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Bloc1s2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsBloc1s2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Bloc1s2
Synonyms Blos2
Function Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (By similarity). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (PubMed:16760431, PubMed:21998198). The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:19546860). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity).
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q6QNY1} Lysosome membrane {ECO:0000250|UniProtKB:Q6QNY1}. Note=Localizes to the centrosomes in a microtubule-dependent manner {ECO:0000250|UniProtKB:Q6QNY1}
Research Areas
Citations (0)

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References

Carninci P.,et al.Science 309:1559-1563(2005).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Starcevic M.,et al.J. Biol. Chem. 279:28393-28401(2004).
Salazar G.,et al.Mol. Biol. Cell 17:4014-4026(2006).
Gdynia G.,et al.Apoptosis 13:437-447(2008).

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$ 293.00
Cat# AI13840
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