|Other Accession||NM_028607, NP_082883|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Predicted||Human, Chicken, Horse, Bovine, Dog|
|Alias Symbol||2410089B13Rik, BLOS2|
|Other Names||Biogenesis of lysosome-related organelles complex 1 subunit 2, BLOC-1 subunit 2, Bloc1s2, Blos2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Bloc1s2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Bloc1s2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May play a role in cell proliferation.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosomes in a microtubule- dependent manner.|
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Provided below are standard protocols that you may find useful for product applications.
Carninci P.,et al.Science 309:1559-1563(2005).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Starcevic M.,et al.J. Biol. Chem. 279:28393-28401(2004).
Salazar G.,et al.Mol. Biol. Cell 17:4014-4026(2006).
Gdynia G.,et al.Apoptosis 13:437-447(2008).
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