Usp12 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9D9M2 |
Other Accession | NM_011669, NP_035799 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 41kDa |
Gene ID | 22217 |
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Alias Symbol | Ubh1 |
Other Names | Ubiquitin carboxyl-terminal hydrolase 12, 3.4.19.12, Deubiquitinating enzyme 12, Ubiquitin thioesterase 12, Ubiquitin-hydrolyzing enzyme 1, Ubiquitin-specific-processing protease 12, Usp12, Ubh1 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Usp12 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Usp12 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Usp12 |
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Synonyms | Ubh1 |
Function | Deubiquitinating enzyme that plays various roles in the regulation of the immune response and inflammation. In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability. During TCR engagement and activation, translocates into the cytoplasm and deubiquitinates its substrates LAT and TRAT1 and prevents their lysosome-dependent degradation to stabilize the TCR signaling complex at the plasma membrane. Plays an essential role in the selective LPS-induced macrophage response through the activation of NF-kappa-B pathway. In addition, promotes that antiviral immune response through targeting DNA sensor IFI16 to inhibit its proteasome- dependent degradation. Participates in the interferon signaling pathway and antiviral response independently of its deubiquitinase activity by maintaining nuclear phosphorylated STAT1 levels via inhibition of its CREBBP-mediated acetylation and subsequent dephosphorylation (By similarity). Plays an intrinsic role in promoting the differentiation, activation and proliferation of CD4(+) T-cell by activating the NF- kappa-B signaling pathway through deubiquitinating and stabilizing B- cell lymphoma/leukemia 10/BCL10 (PubMed:33941870). In myeloid-derived suppressor cells promotes the activation of the NF-kappa-B via deubiquitination and stabilization of RELA (PubMed:35898171). Regulates the 'Lys-63'-linked polyubiquitin chains of BAX and thereby modulates the mitochondrial apoptotic process (By similarity). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:O75317}. Cytoplasm {ECO:0000250|UniProtKB:O75317}. Cell membrane {ECO:0000250|UniProtKB:O75317}. Note=Translocates from the nucleus to the cytosol on TCR stimulation, while it translocates into the nucleus in IFN signaling. USP12/WDR20/WDR48 complex is localized mainly to the plasma membrane. {ECO:0000250|UniProtKB:O75317} |
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Provided below are standard protocols that you may find useful for product applications.
References
Carninci P.,et al.Science 309:1559-1563(2005).
Baek K.-H.,et al.DNA Seq. 13:145-148(2002).
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