|Other Accession||NM_027420, NP_081696|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Other Names||Arpin, Arp2/3 inhibition protein, Arpin|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-2610034B18Rik antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||2610034B18Rik antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence (By similarity).|
|Cellular Location||Cell projection, lamellipodium. Note=Colocalized with the WAVE complex at lamellipodium tip|
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Carninci P.,et al.Science 309:1559-1563(2005).
Dang I.,et al.Nature 503:281-284(2013).
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