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TMEM110 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q86TL2 |
| Other Accession | NM_198563, NP_940965 |
| Reactivity | Human, Rat, Rabbit |
| Predicted | Human, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 33kDa |
| Gene ID | 375346 |
|---|---|
| Alias Symbol | DKFZp667E1121, MGC52022 |
| Other Names | Transmembrane protein 110, TMEM110 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-TMEM110 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TMEM110 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STIMATE (HGNC:30526) |
|---|---|
| Function | Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Colocalizes with STIM1 at ER-plasma membrane (ER-PM) junctions, also called cortical endoplasmic reticulum (ER), in store-depleted calcium cells (PubMed:26644574). May translocate to ER-PM junctions in a STIM1-dependent manner in store- depleted cells (Probable). |
| Tissue Location | Widely expressed.. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 389.00
Cat# AI13873
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