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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   TMEM110 antibody - N-terminal region   

TMEM110 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - TMEM110 antibody - N-terminal region AI13873

    WB Suggested Anti-TMEM110 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:312500
    Positive Control: 721_B cell lysate
    TMEM110 is supported by BioGPS gene expression data to be expressed in 721_B
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q86TL2
Other Accession NM_198563, NP_940965
Reactivity Human, Rat, Rabbit
Predicted Human, Pig
Host Rabbit
Clonality Polyclonal
Calculated MW 33kDa
Additional Information
Gene ID 375346
Alias Symbol DKFZp667E1121, MGC52022
Other Names Transmembrane protein 110, TMEM110
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-TMEM110 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsTMEM110 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM110 (HGNC:30526)
Function Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store- dependent ER-PM junctions (PubMed:26644574).
Cellular Location Endoplasmic reticulum membrane; Multi- pass membrane protein. Note=Colocalizes with STIM1 at ER- plasma membrane (ER-PM) junctions, also called cortical endoplasmic reticulum (ER), in store-depleted calcium cells (PubMed:26644574). May translocate to ER-PM junctions in a STIM1- dependent manner in store-depleted cells (Probable)
Tissue Location Widely expressed.
Research Areas
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$ 293.00
Cat# AI13873
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