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Gtf2h5 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8K2X8 |
| Other Accession | NM_181392, NP_852057 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Bovine, Guinea Pig, Dog |
| Predicted | Rat, Rabbit, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 8kDa |
| Gene ID | 66467 |
|---|---|
| Alias Symbol | 2700017P07Rik, 2810432H05Rik, D17Wsu155e |
| Other Names | General transcription factor IIH subunit 5, General transcription factor IIH polypeptide 5, TFB5 ortholog, TFIIH basal transcription factor complex TTD-A subunit, Gtf2h5, D17Wsu155e |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Gtf2h5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Gtf2h5 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Gtf2h5 {ECO:0000312|MGI:MGI:107227} |
|---|---|
| Synonyms | D17Wsu155e |
| Function | Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell. |
| Cellular Location | Nucleus. Cytoplasm |
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Carninci P.,et al.Science 309:1559-1563(2005).
Matsuoka S.,et al.Science 316:1160-1166(2007).
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$ 389.00
Cat# AI13886
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