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PTPN12 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q05209 |
| Other Accession | NM_002835, NP_002826 |
| Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Rat, Rabbit, Chicken, Horse, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 88kDa |
| Gene ID | 5782 |
|---|---|
| Alias Symbol | PTP-PEST, PTPG1 |
| Other Names | Tyrosine-protein phosphatase non-receptor type 12, 3.1.3.48, PTP-PEST, Protein-tyrosine phosphatase G1, PTPG1, PTPN12 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-PTPN12 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | PTPN12 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTPN12 |
|---|---|
| Function | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P35831}. Cell junction, focal adhesion. Cell projection, podosome {ECO:0000250|UniProtKB:P35831}. Note=Partial translocation to focal adhesion sites may be mediated by interaction with SORBS2. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Takekawa M.,et al.Biochem. Biophys. Res. Commun. 189:1223-1230(1992).
Yang Q.,et al.J. Biol. Chem. 268:6622-6628(1993).
Yang Q.,et al.J. Biol. Chem. 268:17650-17650(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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