|Other Accession||NM_017669, NP_060139|
|Reactivity||Human, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Predicted||Rat, Rabbit, Horse|
|Alias Symbol||FLJ20105, MGC131695, PICH|
|Other Names||DNA excision repair protein ERCC-6-like, 18.104.22.168, ATP-dependent helicase ERCC6-like, PLK1-interacting checkpoint helicase, Tumor antigen BJ-HCC-15, ERCC6L, PICH|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ERCC6L antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ERCC6L antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.|
|Cellular Location||Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset|
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Provided below are standard protocols that you may find useful for product applications.
Baumann C.,et al.Cell 128:101-114(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Xueyuan D.,et al.Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Wang L.-H.,et al.Chromosoma 117:123-135(2008).
Chan K.-L.,et al.EMBO J. 26:3397-3409(2007).
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