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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   ERCC6L antibody - N-terminal region   

ERCC6L antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - ERCC6L antibody - N-terminal region AI14044

    WB Suggested Anti-ERCC6L Antibody Titration: 0.2-1 μg/ml
    Positive Control: THP-1 cell lysate
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q2NKX8
Other Accession NM_017669, NP_060139
Reactivity Human, Rat, Rabbit, Pig, Horse, Bovine, Dog
Predicted Rat, Rabbit, Horse
Host Rabbit
Clonality Polyclonal
Calculated MW 141kDa
Additional Information
Gene ID 54821
Alias Symbol FLJ20105, MGC131695, PICH
Other Names DNA excision repair protein ERCC-6-like,, ATP-dependent helicase ERCC6-like, PLK1-interacting checkpoint helicase, Tumor antigen BJ-HCC-15, ERCC6L, PICH
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-ERCC6L antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsERCC6L antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PICH
Function DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.
Cellular Location Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset
Research Areas
Citations (0)

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Baumann C.,et al.Cell 128:101-114(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Xueyuan D.,et al.Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Wang L.-H.,et al.Chromosoma 117:123-135(2008).
Chan K.-L.,et al.EMBO J. 26:3397-3409(2007).

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$ 293.00
Cat# AI14044
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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