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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Terf2ip antibody - middle region   

Terf2ip antibody - middle region

Rabbit Polyclonal Antibody

  • WB - Terf2ip antibody - middle region AI14093

    WB Suggested Anti-Terf2ip Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Pancreas
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q91VL8
Other Accession NM_020584, NP_065609
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Predicted Mouse, Rat, Rabbit, Pig, Horse, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 31kDa
Additional Information
Gene ID 57321
Alias Symbol Rap1
Other Names Telomeric repeat-binding factor 2-interacting protein 1, TERF2-interacting telomeric protein 1, TRF2-interacting telomeric protein 1, Repressor/activator protein 1 homolog, RAP1 homolog, Terf2ip, Rap1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Terf2ip antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsTerf2ip antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Terf2ip
Synonyms Rap1
Function Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
Cellular Location Nucleus. Cytoplasm. Chromosome. Chromosome, telomere. Note=Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex
Research Areas
Citations (0)

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Carninci P.,et al.Science 309:1559-1563(2005).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Osada N.,et al.Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
Tan M.,et al.Gene 323:1-10(2003).
Ballif B.A.,et al.Mol. Cell. Proteomics 3:1093-1101(2004).

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$ 293.00
Cat# AI14093
(40 western blots)
Availability: 2-3 days
Bulk Size
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