|Application ||WB, IHC|
|Other Accession||NM_020673, NP_065724|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Chicken, Bovine|
|Other Names||Ras-related protein Rab-22A, Rab-22, Rab-14, Rab22a, Rab22|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-RAB22A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||RAB22A antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP- bound active form and a GDP-bound inactive form.|
|Cellular Location||Endosome membrane; Lipid- anchor. Cell membrane; Lipid-anchor. Early endosome. Cell projection, ruffle. Cytoplasmic vesicle. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or Mycobacterium.|
|Tissue Location||Detected in brain and heart, and at lower levels in lung and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
Kussmann S.,et al.Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).
Chavrier P.,et al.Gene 112:261-264(1992).
Olkkonen V.M.,et al.J. Cell Sci. 106:1249-1261(1993).
Zhu H.,et al.Mol. Biol. Cell 20:4720-4729(2009).
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