|Other Accession||NM_001081037, AAL27030|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Chicken, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||Arhgap13, 4930572H05Rik, Srgap1|
|Other Names||SLIT-ROBO Rho GTPase-activating protein 1, srGAP1, Rho GTPase-activating protein 13, Srgap1, Arhgap13|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Srgap1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Srgap1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42 (By similarity).|
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Wong K.,et al.Cell 107:209-221(2001).
Li X.,et al.J. Biol. Chem. 281:28430-28437(2006).
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