|Other Accession||NM_020830, NP_065881|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig|
|Predicted||Human, Mouse, Rat, Rabbit, Chicken, Horse, Bovine, Guinea Pig|
|Alias Symbol||FENS-1, WDF1, ZFYVE17|
|Other Names||WD repeat and FYVE domain-containing protein 1, FENS-1, Phosphoinositide-binding protein 1, WD40- and FYVE domain-containing protein 1, Zinc finger FYVE domain-containing protein 17, WDFY1, KIAA1435, WDF1, ZFYVE17|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-WDFY1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||WDFY1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1435, WDF1, ZFYVE17|
|Function||Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436).|
|Cellular Location||Early endosome|
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Provided below are standard protocols that you may find useful for product applications.
Ridley S.H.,et al.J. Cell Sci. 114:3991-4000(2001).
Hong W.,et al.Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 7:65-73(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
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