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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Sav1 Antibody - C-terminal region   

Sav1 Antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - Sav1 Antibody - C-terminal region AI14144

    WB Suggested Anti-Sav1 Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Brain
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8VEB2
Other Accession NM_022028, NP_071311
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 42kDa
Additional Information
Gene ID 64010
Alias Symbol 1700040G09Rik, Sav, WW45, Wwp3, Wwp4
Other Names Protein salvador homolog 1, 45 kDa WW domain protein, mWW45, Sav1, Ww45, Wwp3
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Sav1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsSav1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Sav1
Synonyms Ww45, Wwp3
Function Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (By similarity).
Cellular Location Nucleus. Cytoplasm
Tissue Location Ubiquitously expressed in adult tissues with the highest level found in testis
Research Areas
Citations (0)

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Valverde P.,et al.Biochem. Biophys. Res. Commun. 276:990-998(2000).
Carninci P.,et al.Science 309:1559-1563(2005).
Lee J.H.,et al.EMBO J. 27:1231-1242(2008).
Lu L.,et al.Proc. Natl. Acad. Sci. U.S.A. 107:1437-1442(2010).

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$ 293.00
Cat# AI14144
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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