|Other Accession||NM_022028, NP_071311|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Alias Symbol||1700040G09Rik, Sav, WW45, Wwp3, Wwp4|
|Other Names||Protein salvador homolog 1, 45 kDa WW domain protein, mWW45, Sav1, Ww45, Wwp3|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Sav1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Sav1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (By similarity).|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Ubiquitously expressed in adult tissues with the highest level found in testis|
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Provided below are standard protocols that you may find useful for product applications.
Valverde P.,et al.Biochem. Biophys. Res. Commun. 276:990-998(2000).
Carninci P.,et al.Science 309:1559-1563(2005).
Lee J.H.,et al.EMBO J. 27:1231-1242(2008).
Lu L.,et al.Proc. Natl. Acad. Sci. U.S.A. 107:1437-1442(2010).
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