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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   UBE2O antibody - middle region   

UBE2O antibody - middle region

Rabbit Polyclonal Antibody

  • WB - UBE2O antibody - middle region AI14151

    WB Suggested Anti-UBE2O Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:62500
    Positive Control: RPMI 8226 cell lysate
    UBE2O is supported by BioGPS gene expression data to be expressed in RPMI 8226
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9C0C9
Other Accession NM_022066, NP_071349
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Chicken, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 141kDa
Additional Information
Gene ID 63893
Alias Symbol E2-230K, FLJ12878, KIAA1734
Other Names E2/E3 hybrid ubiquitin-protein ligase UBE2O, 6.3.2.-,, Ubiquitin carrier protein O, Ubiquitin-conjugating enzyme E2 O, Ubiquitin-conjugating enzyme E2 of 230 kDa, Ubiquitin-conjugating enzyme E2-230K, Ubiquitin-protein ligase O, UBE2O, KIAA1734
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-UBE2O antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsUBE2O antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBE2O
Synonyms KIAA1734
Function E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin- associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853).
Cellular Location Cytoplasm. Nucleus. Note=Mainly localizes to the cytoplasm
Tissue Location Predominantly expressed in skeletal muscle and heart.
Research Areas
Citations (0)

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Nagase T.,et al.DNA Res. 7:347-355(2000).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 293.00
Cat# AI14151
(40 western blots)
Availability: 2-3 days
Bulk Size
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