|Other Accession||NM_019282, NP_062155|
|Reactivity||Human, Mouse, Rat, Rabbit, Goat, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||Cktsf1b1, drm|
|Other Names||Gremlin-1, Cysteine knot superfamily 1, BMP antagonist 1, Down-regulated in Mos-transformed cells protein, Grem1, Cktsf1b1, Drm|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Grem1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Grem1 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed.|
|Tissue Location||Highly expressed in the brain, kidney, spleen, and testis and weakly expressed in the lung and liver Predominantly expressed in differentiated cells as neurons in brain, type I cells in lung and globlet cells in intestine|
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Topol L.Z.,et al.Mol. Cell. Biol. 17:4801-4810(1997).
Chen B.,et al.J. Immunol. 173:5914-5917(2004).
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