|Other Accession||NM_199056, NP_951011|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Chicken, Horse, Bovine, Dog|
|Alias Symbol||1810043M15Rik, InsP6|
|Other Names||Inositol-pentakisphosphate 2-kinase, 22.214.171.124, Inositol-1, 3, 4, 5, 6-pentakisphosphate 2-kinase, Ins(1, 3, 4, 5, 6)P5 2-kinase, InsP5 2-kinase, Ippk|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Ippk antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Ippk antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||In brain, it is expressed throughout the hippocampus (CA1, CA2, CA3 and dentate gyrus), inner layers of the cerebral cortex, and Purkinje cells of the cerebellum. In heart, it is expressed in cardiomyocytes but not in interstitial cells, blood vessels, or valves. Also expressed in testis|
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Provided below are standard protocols that you may find useful for product applications.
Carninci P.,et al.Science 309:1559-1563(2005).
Verbsky J.,et al.Proc. Natl. Acad. Sci. U.S.A. 102:8448-8453(2005).
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