|Other Accession||NM_005679, NP_005670|
|Reactivity||Human, Mouse, Rat, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Pig, Horse, Bovine, Dog|
|Alias Symbol||MGC:39976, SL1, TAFI110, TAFI95|
|Other Names||TATA box-binding protein-associated factor RNA polymerase I subunit C, RNA polymerase I-specific TBP-associated factor 110 kDa, TAFI110, TATA box-binding protein-associated factor 1C, TBP-associated factor 1C, Transcription initiation factor SL1/TIF-IB subunit C, TAF1C|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-TAF1C antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TAF1C antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.|
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Provided below are standard protocols that you may find useful for product applications.
Comai L.,et al.Science 266:1966-1972(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Martin J.,et al.Nature 432:988-994(2004).
Zhai W.,et al.Mol. Cell. Biol. 20:5930-5938(2000).
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