|Other Accession||NM_016703, NP_057912|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Other Names||Prolactin regulatory element-binding protein, Mammalian guanine nucleotide exchange factor mSec12, Preb, Sec12|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Preb antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Preb Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER.|
|Cellular Location||Nucleus. Membrane; Single-pass membrane protein. Endoplasmic reticulum|
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Provided below are standard protocols that you may find useful for product applications.
Edgar A.J.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Taylor Clelland C.L.,et al.Genomics 63:391-399(2000).
Weissman J.T.,et al.Traffic 2:465-475(2001).
Sacksteder C.A.,et al.Biochemistry 45:8009-8022(2006).
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