|Other Accession||NM_007892, NP_031918|
|Reactivity||Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Pig, Guinea Pig, Dog|
|Alias Symbol||AU024671, E2F-5|
|Other Names||Transcription factor E2F5, E2F-5, E2f5|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-E2f5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||E2f5 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor- initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.|
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Provided below are standard protocols that you may find useful for product applications.
Buck V.,et al.Oncogene 11:31-38(1995).
Carninci P.,et al.Science 309:1559-1563(2005).
Dagnino L.,et al.Mech. Dev. 66:13-25(1997).
Dagnino L.,et al.Cell Growth Differ. 8:553-563(1997).
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