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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   ACD antibody - C-terminal region   

ACD antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - ACD antibody - C-terminal region AI14267

    WB Suggested Anti-ACD Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:62500
    Positive Control: Human brain
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96AP0
Other Accession NM_001082486, NP_001075955
Reactivity Human
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 58kDa
Additional Information
Gene ID 65057
Alias Symbol PIP1, PTOP, TINT1, TPP1
Other Names Adrenocortical dysplasia protein homolog, POT1 and TIN2-interacting protein, ACD, PIP1, PTOP, TINT1, TPP1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-ACD antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsACD antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACD
Synonyms PIP1, PTOP, TINT1, TPP1
Function Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis.
Cellular Location Nucleus. Chromosome, telomere
Research Areas
Citations (0)

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Liu D.,et al.Nat. Cell Biol. 6:673-680(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Keegan C.E.,et al.Hum. Mol. Genet. 14:113-123(2005).
Ye J.Z.-S.,et al.Genes Dev. 18:1649-1654(2004).

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$ 293.00
Cat# AI14267
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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