|Other Accession||NM_001082486, NP_001075955|
|Alias Symbol||PIP1, PTOP, TINT1, TPP1|
|Other Names||Adrenocortical dysplasia protein homolog, POT1 and TIN2-interacting protein, ACD, PIP1, PTOP, TINT1, TPP1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ACD antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ACD antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||PIP1, PTOP, TINT1, TPP1|
|Function||Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.|
|Cellular Location||Nucleus Chromosome, telomere|
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Liu D.,et al.Nat. Cell Biol. 6:673-680(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Keegan C.E.,et al.Hum. Mol. Genet. 14:113-123(2005).
Ye J.Z.-S.,et al.Genes Dev. 18:1649-1654(2004).
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