|Other Accession||NM_001082486, NP_001075955|
|Alias Symbol||PIP1, PTOP, TINT1, TPP1|
|Other Names||Adrenocortical dysplasia protein homolog, POT1 and TIN2-interacting protein, ACD, PIP1, PTOP, TINT1, TPP1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ACD antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ACD antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||PIP1, PTOP, TINT1, TPP1|
|Function||Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis.|
|Cellular Location||Nucleus. Chromosome, telomere|
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Liu D.,et al.Nat. Cell Biol. 6:673-680(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Keegan C.E.,et al.Hum. Mol. Genet. 14:113-123(2005).
Ye J.Z.-S.,et al.Genes Dev. 18:1649-1654(2004).
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