|Other Accession||NM_080668, NP_542399|
|Alias Symbol||MGC16386, SORORIN|
|Other Names||Sororin, Cell division cycle-associated protein 5, p35, CDCA5|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-CDCA5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CDCA5 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.|
|Cellular Location||Nucleus. Chromosome. Cytoplasm. Note=Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown|
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Provided below are standard protocols that you may find useful for product applications.
Walker M.G.,et al.Curr. Cancer Drug Targets 1:73-83(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Rankin S.,et al.Mol. Cell 18:185-200(2005).
Rankin S.,et al.Mol. Cell 18:609-609(2005).
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