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>   home   >   Products   >   Primary Antibodies   >   H2AFY antibody - N-terminal region   

H2AFY antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - H2AFY antibody - N-terminal region AI14276

    WB Suggested Anti-H2AFY Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:12500
    Positive Control: MCF7 cell lysate
  • WB - H2AFY antibody - N-terminal region AI14276

    Host: Rabbit
    Target Name: H2AFY
    Sample Tissue: MCF7
    Antibody Dilution: 1.0μg/mlH2AFY is strongly supported by BioGPS gene expression data to be expressed in Human MCF7 cells
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75367
Other Accession NM_001040158, NP_001035248
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Chicken, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 39kDa
Additional Information
Gene ID 9555
Alias Symbol H2A.y, H2A/y, H2AF12M, H2AFJ, MACROH2A1.1, mH2A1, macroH2A1.2
Other Names Core histone macro-H2A.1, Histone macroH2A1, mH2A1, Histone H2A.y, H2A/y, Medulloblastoma antigen MU-MB-50.205, H2AFY, MACROH2A1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-H2AFY antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsH2AFY antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name H2AFY
Synonyms MACROH2A1
Function Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP- ribose, and may be involved in ADP-ribose-mediated chromatin modulation.
Cellular Location Nucleus. Chromosome. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin
Tissue Location Ubiquitous..
Citations (0)

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Lee Y.,et al.Biochim. Biophys. Acta 1399:73-77(1998).
Mao M.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Behrends U.,et al.Int. J. Cancer 106:244-251(2003).

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$ 293.00
Cat# AI14276
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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