|Other Accession||NM_024039, NP_076944|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine|
|Predicted||Human, Mouse, Rat, Rabbit, Bovine|
|Alias Symbol||2510025F08Rik, KNTC2AP, MGC2488, MTW1, hMis12|
|Other Names||Protein MIS12 homolog, MIS12 (HGNC:24967)|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-MIS12 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||MIS12 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachments (PubMed:23891108).|
|Cellular Location||Chromosome, centromere, kinetochore Note=Associated with the kinetochore|
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Provided below are standard protocols that you may find useful for product applications.
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Goshima G.,et al.J. Cell Biol. 160:25-39(2003).
Obuse C.,et al.Nat. Cell Biol. 6:1135-1141(2004).
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