Ccnb1ip1 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | D3Z3K2 |
Other Accession | NM_001111119, NP_001104589 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 31kDa |
Gene ID | 239083 |
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Alias Symbol | Gm288, Hei10, mei4 |
Other Names | E3 ubiquitin-protein ligase CCNB1IP1, 6.3.2.-, Cyclin-B1-interacting protein 1, Ccnb1ip1, Gm288, Hei10, Mei4 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Ccnb1ip1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Ccnb1ip1 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Ccnb1ip1 |
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Synonyms | Gm288, Hei10, Mei4 |
Function | Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non- crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. |
Cellular Location | Nucleus. Chromosome. Note=Associates to the synaptonemal complex |
Tissue Location | Expressed predominantly in the testes and 17 day embryos (corresponding to prophase I in females). Weakly or not expressed in other tissues. |
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Provided below are standard protocols that you may find useful for product applications.
References
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Ward J.O.,et al.PLoS Genet. 3:E139-E139(2007).
Strong E.R.,et al.Genes (Basel) 1:440-451(2010).
Qiao H.,et al.Nat. Genet. 46:194-199(2014).
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