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KLHL15 antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - KLHL15 antibody - middle region AI14298

    WB Suggested Anti-KLHL15 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:312500
    Positive Control: 293T cell lysate
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q96M94
Other Accession NM_030624, NP_085127
Reactivity Human, Mouse, Rat, Horse, Bovine, Guinea Pig, Dog
Predicted Mouse, Rat, Rabbit, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 66kDa
Additional Information
Gene ID 80311
Alias Symbol MGC126148, MGC126149
Other Names Kelch-like protein 15, KLHL15, KIAA1677
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-KLHL15 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsKLHL15 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLHL15
Synonyms KIAA1677
Function Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex (PubMed:14528312). Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits (PubMed:23135275). Acts as an adapter for CUL3 to target the DNA- end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non- homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:27561354).
Cellular Location Nucleus.
Research Areas
Citations (0)

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References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nagase T.,et al.DNA Res. 7:347-355(2000).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Furukawa M.,et al.Nat. Cell Biol. 5:1001-1007(2003).

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$ 293.00
Cat# AI14298
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