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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   JARID2 antibody - N-terminal region   

JARID2 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - JARID2 antibody - N-terminal region AI14331

    WB Suggested Anti-JARID2 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:312500
    Positive Control: Hela cell lysate
    JARID2 is supported by BioGPS gene expression data to be expressed in HeLa
  • WB - JARID2 antibody - N-terminal region AI14331

    Target Name:JARID2
    Sample Tissue:721_B
    Antibody Dilution: 1.0μg/ml
    JARID2 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92833
Other Accession NM_017566, NP_004964
Reactivity Human, Mouse, Rat, Rabbit, Pig, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rabbit, Pig, Bovine, Guinea Pig
Host Rabbit
Clonality Polyclonal
Calculated MW 139kDa
Additional Information
Gene ID 3720
Alias Symbol JMJ
Other Names Protein Jumonji, Jumonji/ARID domain-containing protein 2, JARID2, JMJ
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-JARID2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsJARID2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms JMJ
Function Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:20075857}. Note=Colocalizes with the PRC2 complex on chromatin
Tissue Location During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells
Research Areas
Citations (0)

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Berge-Lefranc J.-L.,et al.Hum. Mol. Genet. 5:1637-1641(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Choudhary C.,et al.Science 325:834-840(2009).

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$ 293.00
Cat# AI14331
(40 western blots)
Availability: 2-3 days
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