|Other Accession||NM_003768, NP_003759|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Alias Symbol||HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED|
|Other Names||Astrocytic phosphoprotein PEA-15, 15 kDa phosphoprotein enriched in astrocytes, Pea15|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-PEA15 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PEA15 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity).|
|Cellular Location||Cytoplasm. Note=Associated with microtubules.|
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Provided below are standard protocols that you may find useful for product applications.
Chneiweiss H.M.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Lubec G.,et al.Submitted (APR-2007) to UniProtKB.
Hoffert J.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
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