|Other Accession||NM_019279, NP_062152|
|Reactivity||Human, Mouse, Rat, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Pig, Bovine, Guinea Pig, Dog|
|Other Names||ProSAAS, Proprotein convertase subtilisin/kexin type 1 inhibitor, Proprotein convertase 1 inhibitor, pro-SAAS, KEP, Big SAAS, b-SAAS, Little SAAS, l-SAAS, Big PEN-LEN, b-PEN-LEN, SAAS CT(1-49), PEN, PEN-20, Little LEN, l-LEN, Big LEN, b-LEN, SAAS CT(25-40), Pcsk1n|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Pcsk1n antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Pcsk1n Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 65 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known (By similarity).|
|Cellular Location||Secreted. Golgi apparatus, trans-Golgi network|
|Tissue Location||Expressed in adult brain (all major structural regions), adrenal gland (medulla) and spinal chord (dorsal and ventral horn). Expressed in pancreatic islands|
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Provided below are standard protocols that you may find useful for product applications.
Fricker L.,et al.J. Neurosci. 20:639-648(2000).
Donadel G.,et al.Neuroendocrinology 67:190-196(1998).
Qian Y.,et al.J. Biol. Chem. 275:23596-23601(2000).
Mzhavia N.,et al.Biochem. J. 361:67-76(2002).
Morgan D.J.,et al.J. Neurochem. 93:1454-1462(2005).
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