|Other Accession||NM_016723, NP_057932|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog|
|Other Names||Ubiquitin carboxyl-terminal hydrolase isozyme L3, UCH-L3, 22.214.171.124, Ubiquitin thioesterase L3, Uchl3|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Uchl3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Uchl3 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome.|
|Tissue Location||Ubiquitously expressed, with highest levels in brain, liver, heart, thymus, kidney and testis. Highly expressed in the cauda epididymidis, in meiotic pachytene spermatocytes and post-meiotic spematids. In the retina, enriched in the photoreceptor inner segment.|
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Provided below are standard protocols that you may find useful for product applications.
Kurihara L.J.,et al.Mol. Cell. Biol. 20:2498-2504(2000).
Osawa Y.,et al.Biochem. Biophys. Res. Commun. 283:627-633(2001).
Wada H.,et al.Biochem. Biophys. Res. Commun. 251:688-692(1998).
Wood M.A.,et al.Hippocampus 15:610-621(2005).
Sano Y.,et al.Am. J. Pathol. 169:132-141(2006).
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