Uchl3 Antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9JKB1 |
Other Accession | NM_016723, NP_057932 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 26kDa |
Gene ID | 50933 |
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Other Names | Ubiquitin carboxyl-terminal hydrolase isozyme L3, UCH-L3, 3.4.19.12, Ubiquitin thioesterase L3, Uchl3 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Uchl3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Uchl3 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Uchl3 |
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Function | Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome. |
Cellular Location | Cytoplasm |
Tissue Location | Ubiquitously expressed, with highest levels in brain, liver, heart, thymus, kidney and testis. Highly expressed in the cauda epididymidis, in meiotic pachytene spermatocytes and post-meiotic spematids. In the retina, enriched in the photoreceptor inner segment |
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Provided below are standard protocols that you may find useful for product applications.
References
Kurihara L.J.,et al.Mol. Cell. Biol. 20:2498-2504(2000).
Osawa Y.,et al.Biochem. Biophys. Res. Commun. 283:627-633(2001).
Wada H.,et al.Biochem. Biophys. Res. Commun. 251:688-692(1998).
Wood M.A.,et al.Hippocampus 15:610-621(2005).
Sano Y.,et al.Am. J. Pathol. 169:132-141(2006).
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