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Uchl3 Antibody - middle region

Rabbit Polyclonal Antibody

  • WB - Uchl3 Antibody - middle region AI14379

    Host: Rabbit
    Target Name: Uchl3
    Sample Tissue: Mouse Testis lysates
    Antibody Dilution: 1.0μg/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9JKB1
Other Accession NM_016723, NP_057932
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 26kDa
Additional Information
Gene ID 50933
Other Names Ubiquitin carboxyl-terminal hydrolase isozyme L3, UCH-L3,, Ubiquitin thioesterase L3, Uchl3
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Uchl3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsUchl3 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Uchl3
Function Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome.
Cellular Location Cytoplasm
Tissue Location Ubiquitously expressed, with highest levels in brain, liver, heart, thymus, kidney and testis. Highly expressed in the cauda epididymidis, in meiotic pachytene spermatocytes and post-meiotic spematids. In the retina, enriched in the photoreceptor inner segment.
Research Areas
Citations (0)

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Kurihara L.J.,et al.Mol. Cell. Biol. 20:2498-2504(2000).
Osawa Y.,et al.Biochem. Biophys. Res. Commun. 283:627-633(2001).
Wada H.,et al.Biochem. Biophys. Res. Commun. 251:688-692(1998).
Wood M.A.,et al.Hippocampus 15:610-621(2005).
Sano Y.,et al.Am. J. Pathol. 169:132-141(2006).

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$ 293.00
Cat# AI14379
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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