USP35 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9P2H5 |
Other Accession | NM_020798, NP_065849 |
Reactivity | Human, Mouse, Rat, Rabbit, Goat, Horse, Yeast, Bovine, Dog |
Predicted | Human, Rat, Rabbit, Bovine, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 113kDa |
Gene ID | 57558 |
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Other Names | Ubiquitin carboxyl-terminal hydrolase 35, 3.4.19.12, Deubiquitinating enzyme 35, Ubiquitin thioesterase 35, Ubiquitin-specific-processing protease 35, USP35, KIAA1372, USP34 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-USP35 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | USP35 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | USP35 |
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Synonyms | KIAA1372, USP34 |
Function | Deubiquitinase that plays a role in different processes including cell cycle regulation, mitophagy or endoplasmic reticulum stress (PubMed:26348204, PubMed:29449677, PubMed:37004621). Inhibits TNFalpha-induced NF-kappa-B activation through stabilizing TNIP2 protein via deubiquitination (PubMed:26348204). Plays an essential role during mitosis by deubiquitinating and thereby regulating the levels of Aurora B/AURKB protein (PubMed:29449677). In addition, regulates the protein levels of other key component of the chromosomal passenger complex (CPC) such as survivin/BIRC5 or Borealin/CDCA8 by enhancing their stability (PubMed:34438346). Regulates the degradation of mitochondria through the process of autophagy termed mitophagy (PubMed:25915564). |
Cellular Location | Cytoplasm. Mitochondrion. Note=Only associates with polarized mitochondria, and rapidly translocates to the cytosol during mitophagy. |
Tissue Location | Expressed in testis, pancreas and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
References
Quesada V.,et al.Biochem. Biophys. Res. Commun. 314:54-62(2004).
Nagase T.,et al.DNA Res. 7:65-73(2000).
Taylor T.D.,et al.Nature 440:497-500(2006).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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