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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   POFUT1 antibody - middle region   

POFUT1 antibody - middle region

Rabbit Polyclonal Antibody

  • WB - POFUT1 antibody - middle region AI14396

    WB Suggested Anti-POFUT1 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:312500
    Positive Control: PANC1 cell lysate
    POFUT1 is strongly supported by BioGPS gene expression data to be expressed in Human PANC1 cells
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6EV69
Other Accession NM_015352, NP_056167
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Predicted Mouse, Rabbit, Pig, Chicken, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 41kDa
Additional Information
Gene ID 449504
Alias Symbol FUT12, KIAA0180, MGC2482, O-FUT, O-Fuc-T, O-FucT-1
Other Names GDP-fucose protein O-fucosyltransferase 1,, Peptide-O-fucosyltransferase 1, O-FucT-1, POFUT1, FUT12
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-POFUT1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsPOFUT1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FUT12
Function Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs) (By similarity).
Cellular Location Endoplasmic reticulum.
Research Areas
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Martinez-Duncker I.,et al.Glycobiology 13:1C-5C(2003).

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$ 293.00
Cat# AI14396
(40 western blots)
Availability: 2-3 days
Bulk Size
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