|Application ||WB, IHC|
|Other Accession||NM_009306, NP_033332|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Chicken, Horse, Bovine, Dog|
|Alias Symbol||AW124717, G630098F17Rik, SytI|
|Other Names||Synaptotagmin-1, Synaptotagmin I, SytI, p65, Syt1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Syt1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Syt1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules|
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Provided below are standard protocols that you may find useful for product applications.
Fukuda M.,et al.J. Biol. Chem. 269:29206-29211(1994).
Carninci P.,et al.Science 309:1559-1563(2005).
Lubec G.,et al.Submitted (JAN-2009) to UniProtKB.
Lazzell D.R.,et al.J. Biol. Chem. 279:52124-52131(2004).
Ballif B.A.,et al.J. Proteome Res. 7:311-318(2008).
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